Just posted this on a Facebook friend's status update about unsubscribing from junk emails ...
Do NOT use the unsubscribe on junk emails unless you know they are a reputable company.
Unsubscribing indicates you read it and signals them to put you on different lists.
Instead, just delete them by marking them as spam.
If you're a little advanced, you can filter emails to go straight to your junk email box ... For instance "Cialis" or "Mortgage enhancement offer" <~ words neither of which the average friend or relative is going to send you in email .
DO check your junk email folder once a month to make sure you're getting all your emails. I send emails from my personal domains - outlook sees these as spammy addresses.